Dr. Ahmed Mohamed Al-Abd

Education

• B. Pharm from Ain Shams University, Egypt in 2000
• MSc in Pharmacology and Toxicology from Ain Shams University, Egypt in 2004
• Ph.D. fellowship & courses from The Catholic University of Korea, Korea in 2008
• Ph.D. from Beni-Suef University, Beni-Suef, Egypt in 2011
• Post Doc fellow at Center for Pharmaceutical Biotechnology and Nanomedicine (CPBN), Bouvé College of Health Sciences, Northeastern University, Boston, USA in 2014.

Research Interest

• In vitro cancer modelling and simulating preclinical solid tumour microenvironment.
• Pharmacodynamic-pharmacokinetic interaction within solid tumours microenvironment.
• Drug Delivery Systems for solid tumour: optimization and spatial PK-PD interaction.

Selected Publications

• Alqarni, A., Alamoudi, A., Allam, R., Ajabnoor, G., Harakeh, S., & Al-Abd, A.M. (2022). The influence of antioxidant dietary-derived polyphenolic combination on breast cancer: Molecular study. Biomedicine &Amp; Pharmacotherapy, 149, 112835. doi: 10.1016/j.biopha.2022.112835. [link]
• Elawady, T., Al-Abd, A.M., Khedr, A., EL-Enany, N., & Belal, F. (2022). LC-MS/MS monitoring of the colorectal carcinoma cellular uptake and entrapment of sorafenib and its N-oxide active metabolite. Journal Of Pharmaceutical And Biomedical Analysis, 213, 114687. doi: 10.1016/j.jpba.2022.114687. [link]
• Mohamed, T., Elshamy, A., Ibrahim, M., Atia, M., Ahmed, R., Ali, S., Mahdy, K., Alshammari, S., Al-Abd, M.A., Moustafa, M., Farrag, A. and Hegazy, M., 2021. Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative. Biomolecules, 11(8), p.1247. [link]
• Abuhijjleh, R.K., Shabbir, S., Al-Abd, A.M., Jiaan, N., Alshamil, S., El-labbad, E.M., & Khalifa, S. (2021). Bioactive marine metabolites derived from the Persian Gulf compared to the Red Sea: similar environments and wide gap in drug discovery. Peerj, 9, e11778. doi: 10.7717/peerj.11778. [link]
• Algehani, R., Abou Khouzam, R., Hegazy, G., Alamoudi, A., El-Halawany, A., El Dine, R., Ajabnoor, G., Al-Abbasi, F., Baghdadi, M., Elsayed, I., Hattori, M. and Al-Abd, A.M. 2021. Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells. Biomedicine & Pharmacotherapy, 140, p.111730. [link]
• El-Readi, M., Al-Abd, A.M., Althubiti, M., Almaimani, R., Al-Amoodi, H., Ashour, M., Wink, M. and Eid, S., 2021. Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites. Frontiers in Pharmacology, 12. [link]
• A. Mahrous, E., Al-Abd, A.M., Salama, M., Fathy, M., Soliman, F. and R. Saber, F., 2021. Cattleianal and Cattleianone: Two New Meroterpenoids from Psidium cattleianum Leaves and Their Selective Antiproliferative Action against Human Carcinoma Cells. Molecules, 26(10), p.2891. [link]
• Lakshmanan, V.K., Kim. B., Ojha. S., Al-Abd. A.M., Shin. M.G., Jung. Y.D. Preparation and characterization of an elastin nanogel with enhanced biocompatibility and improved entrapment efficiency in prostate cancer cells. Materials Express. 2021 Jan 1;11(1):16-27. [link]
• Klionsky, D.J., Abdel-Aziz, A.K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M.H., Abudu, Y.P., Acevedo-Arozena, A., Adamopoulos, I.E., Adeli, K., Adolph, T.E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B.B., Agnello, M., Agostinis, P., Agrewala, J.N., Agrotis, A., Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro, U., Aits, S., Aizawa, S., Akkoc, Y., Akoumianaki, T., Akpinar, H.A., Al-Abd, A.M., Al-Akra, L., Al-Gharaibeh, A., Alaoui-Jamali, M.A., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021;1-382. [link]
• Elbehairi, S. E. I., Ezzat Ahmed, A., Alshati, A. A., Al-Kahtani, M. A., Alfaifi, M. Y., Alsyaad, K. M., Alalmie, A. Y. A. ., Elimam Ahamed, M. M., Moustafa, M. F., Alhag, S. K., Al-Abd, A. M., & Abbas, A. M. (2020). Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines. EXCLI Journal, 19, 1282-1294. [link]
• Henidi, H., Al-Abbasi, F., El-Moselhy, M., El-Bassossy, H., & Al-Abd, A. (2020). Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity. Oxidative Medicine And Cellular Longevity, 2020, 1-14. doi: 10.1155/2020/8157640. [link]
• Bawadood, A., Al-Abbasi, F., Anwar, F., El-Halawany, A., & Al-Abd, A. (2020). 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway. Biomedicine & Pharmacotherapy, 128, 110302. doi: 10.1016/j.biopha.2020.110302. [link]
• Al-Abd, M. A. (2020). Chemo-sensitizing agents from natural origin for colorectal cancer: Pharmacodynamic and cellular pharmacokinetics approaches. In Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies. (1st ed.). Elsevier. [link]
• Al-Abd, M. A., Khedr, A., Atteiah,S, G., & Al-Abbasi, F, A. (2020). Intra-tumoral drug concentration mapping within solid tumor micro-milieu using in-vitro model and doxorubicin as a model drug. Saudi Pharmaceutical Journal. doi: 10.1016/j.jsps.2020.05.001. [link]
• Bashmail. H.A., Alamoudi. A.A., Noorwali. A., Hegazy. G.A., Ajabnoor. G.M., Al-Abd. A.M. Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism. Molecules. 2020 Jan;25(2):426. [link]
• El-Shitany NA, Abbas AT, Ali SS, Eid B, Harakeh S, Neamatallah Z, Al-Abd AM, Mousa S. Nanoparticles Ellagic Acid Protects Against Cisplatin-induced Hepatotoxicity in Rats Without Inhibiting its Cytotoxic Activity. Int. J. Pharmacol. 2019;15: 465-477 – [link]
• Henidi, H. A., Al-Abd, A. M., Al-Abbasi, F. A., BinMahfouz, H. A., & El-Deeb, I. M. (2019). Design and synthesis of novel phenylaminopyrimidines with antiproliferative activity against colorectal cancer. RSC Advances, 9(37), 21578-21586. [Link]
• Fekry  MI., Ezzat SM., Salama, M.M., Alshehri, O.Y, Al-Abd AM.(2019). Bioactive glycoalkaloides isolated from Solanum melongena fruit peels with potential anticancer properties against hepatocellular carcinoma cells.  Scientific Reports, 9, Article number: 1746 [Link] 
• El-Sawy HS, Al-Abd AM, Ahmed TA, El-Say KM, Torchilin VP. (2018). Stimuli-responsive nano-architectures drug delivery systems to solid tumor micromilieu: past, present and future perspectives. ACS Nano. 12(11), 10636-10664 [Link]
• Bashmail HA, Alamoudi AA, Noorwali A, Hegazy GA, Ajabnoor G, Choudhry H and Al-Abd AM. (2018). Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities. Scientific Reports; 8(1): 11674. [link]
• Baghdadi MA, Al-abbasi FA, El-Halawany AM, Aseeri AH, Al-Abd AM. (2018). Anticancer profiling for coumarins and related O-naphthoquinones from Mansonia gagei against solid tumor cells in-vitro. Molecules; 23(5).  [Link]
• Alahdal AM, Asfour HZ, Ahmed SA, Noor AO, Al-Abd AM, Elfaky MA and Elhady SS. (2018). Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus. Molecules; 23(4). [Link]
• Allam RM, Al-Abd AM, Khedr A, Sharaf OA, Nofal SM, Khalifa AE, Mosli HA, Abdel-Naim AB. (2018). Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells. Toxicology Letters 2018; 291:77-85.   [Link]
• Ahmed TA, Al-Abd AM. (2018). Effect of finasteride particle size reduction on its pharmacokinetic, tissue distribution and cellular permeation. Drug Delivery;25(1):555-563. [Link]
• Kassem MA, Megahed MA, Abu Elyazid SK, Abd-Allah FI, Abdelghany TM, Al-Abd AM, El-Say KM. (2018). Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells. AAPS PharmSciTech; 19(4):1529-1543. [Link]
• Abdel-Naim AB, Alghamdi AA, Algandaby MM, Al-Abbasi FA, Al-Abd AM, Eid BG, Abdallah HM, El-Halawany AM. (2018). Rutin isolated from Chrozophora tinctoria enhances bone cell proliferation and ossification markers. Oxidative Medicine and Cellular Longevity 2018; 2018:5106469.  [Link]
• Alaufi OM, Noorwali A, Zahran F, Al-Abd AM, Al-Attas S. (2017). Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro. Scientific Report;7(1):13131.  [Link]
• Al-Abd AM, Alamoudi AJ, Abdel-Naim AB, Neamatallah TA, Ashour OM. (2017). Anti- angiogenic agents for the treatment of solid tumors: potential pathways, therapy and current strategies – A review. Journal of Advanced Research; 8(6): 591-605 [Link]
• Abdel-Naim AB, Alghamdi AA, Algandaby MM, Al-Abbasi FA, Al-Abd AM, Abdallah HM, El-Halawany AM, Hattori M. (2017). Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells. Molecules.; 22(9). [Link]
• Mohamed GA, Al-Abd AM, El-halawany AM, Abdalla HM, Ibrahim SRM. (2017). New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines. J. Ethnopharmacology;198:302-312 [Link]
• El-Araby ME, Omar AM, Khayat MT, Assiri HA and Al-Abd AM. (2017). Molecular mimics of classic P-glycoprotein inhibitors as multidrug resistance suppressors and their synergistic effect on paclitaxel. Plos One; 12(1):e0168938. [Link]
• Khaleel SA, Al-Abd AM, Ali AA, Abdel-Naim AB. (2016). Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. Scientific Reports; 6:36855. [Link]
• Al-Abbasi FA, Alghamdi EA, Baghdadi MA, Alamoudi AJ, El-Halawany AM, El-Bassossy HM, Aseeri AS and Al-Abd AM. (2016). Gingerol Synergizes the Cytotoxic Effects of doxorubicin against liver cancer cells and protects from its vascular toxicity. Molecules; 21(7). [Link]
• ElHady SS, Al-Abd AM, El-Halawany AM, Alahdal AM, Hassanean HA, Ahmed SA. (2016).Antiproliferative scalarane-based metabolites from the red sea sponge hyrtios erectus. Marine Drugs.; 14(7).  [Link]
• Mahmoud AM, Aboul-Soud MA, Han J, Al-Sheikh YA, Al-Abd AM, El-Shemy HA. (2016). Transcriptional profiling of breast cancer cells in response to mevinolin: Evidence of cell cycle arrest, DNA degradation and apoptosis. Int J Oncol.; 48(5): 1886-94. [Link]
• Abdel-Lateff A, Al-Abd AM, Alahdal AM, Alarif WM, Ayyad SE, Al-Lihaibi SS, Hegazy ME, Al Mohammadi A, Abdelghany TM, Abdel-Naim AB, Moustafa MA, Banjer ZM, Azhar AS. (2016). Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells. Z Naturforsch C.; 71(1-2): 29-35. [Link]
• Aboul‑Soud MAM, El‑Shemy HA, Aboul‑Enein KM, Mahmoud AM, Al‑Abd AM, Lightfoot DA. (2016). Effects of plant‑derived anti‑leukemic drugs on individualized leukemic cell population profiles in Egyptian patients. Oncology Letters; 11(1): 642-648. [Link]
• Al-Abd AM, Aljehani ZK, Gazzaz RW, Fakhri SH, Jabbad AH, Alahdal AM, Torchilin VP. (2015). Pharmacokinetic strategies to improve drug penetration and entrapment within solid tumors. Journal of Controlled Release  10; 219: 269-77. [Link]
• Abdel-Latif GA, Al-Abd AM, Tadros MG, Al-Abbasi FA, Khalifa AE, Abdel-Naim AB. (2015). The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Scientific Report; 5: 12054. [Link]
• Al-Abd AM, Al-Abbasi FA, Torchilin VP. (2015). Intratumoral pharmacokinetics: challenges to nanobiomaterials. Current Pharmaceutical Design; 21(22), 3208-3214. [Link]
• El-Halawany AM, Al-Abd AM, Abdallah HM and El-Din RS. (2015). P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers. Journal of Advanced Research; 6 (1), 45-62 [Link]
• Habib CN, Al-Abd AM, Tolba MF, Khalifa AE, Khedr A, Mosli HA, Abdel-Naim AB. (2015). Leptin influences estrogen metabolism and accelerates prostate cell proliferation. Life Sciences; 121, 10-15 [Link]
• Al-Abd AM, Al-Abbasi FA, Nofal SM, Khalifa AE, Williams RO, El-Eraky WI, Nagy AA, Abdel-Naim AB. (2014). Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. Plos One  ; 9(11): e111843. [Link]
• Soliman FM, Fathy MM, Salama MM, Al-Abd AM, Saber FR and El-Halawany AM. (2014). Cytotoxic activity of acyl phloroglucinols isolated from the leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt. Scientific Reports; 4:5410. [Link]
• Abou El-Ella DA, Hussein MM, Serya RA, Abdel Naby RM, Al-Abd AM, Saleh DO, El-Eraky WI, Abouzid KA. (2014). Molecular design and synthesis of 1,4-disubstituted piperazines as α1-adrenergic receptor blockers. Bioorg Chem.;54C:21-30 [Link]
• Abdallah HM, Al-Abd AM, Asaad GF, Abdel-Naim AB, El-halawany AM. (2014). Isolation of antiosteoporotic compounds from seeds of Sophora japonica. PLos One;9(6):e98559. [Link]